Watch String Cheese Debut ‘The Harder They Come’ With ALO’s Dan Lebowitz In Oakland Opener

first_imgThe String Cheese Incident rolled into Oakland for the second night of their March Madness tour, coming out firing for a great night of music. The first set featured mostly Cheese originals, starting with “BollyMunster” and “Got What He Wanted.” The group jammed out the transition into “MLT” and rolled right along, including a cover of “Don’t It Make You Wanna Dance.”Easily one of the main highlights of the show was the second set opening version of “The Harder They Come.” The band welcomed guitarist Dan “Lebo” Lebowitz of ALO for the Jimmy Cliff cover, jamming out to the fans’ delights. What a celebration!Listen To String Cheese’s Cover-Heavy Tour Opener In Reno [Full Audio]Watch “The Harder They Come” here, courtesy of MrTopDogger:The set continued with “Let’s Go Outside,” also featuring ‘Lebo,’ and closed out with great versions of “Black Clouds,” “Way Back Home” and “Valley Of The Jig” – classics from the band’s deep catalog. The encore of “Outside and Inside” and U2’s “Mysterious Ways” brought the show to a close. Fear not Oakland, because Cheese is coming back for you tonight!Check out the setlist below, via Friends of Cheese:Setlist: The String Cheese Incident at Fox Theater, Oakland, CA – 3/11/16SET 1: BollyMunster, Got What He Wanted > MLT, Black & White, Don’t It Make You Wanna Dance, Sweet Spot, Looking Glass$ > Can’t Wait Another DaySET 2: The Harder They Come*, Let’s Go Outside*, Black Clouds, Way Back Home, Valley of the JigENCORE: Outside and Inside, Mysterious Ways* = w/ Dan ‘Lebo’ Lebowitz$ = Eleanor Rigby teaseslast_img read more

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A hidden genetic code

first_imgHarvard scientists say they’ve solved a mystery that’s nearly as old as science’s understanding of the genetic code.Though the genetic code, the cell’s set of rules for transcribing DNA into RNA and translating RNA into proteins, has been understood for decades, scientists have puzzled over what seemed like a mathematical incongruity in the system. To manufacture proteins, cells rely on RNA, which like DNA is made up of nucleotides that have one of four bases. Cells “read” those bases in groups of three to translate RNA into  amino acids, which are used to build proteins.While there are 64 possible ways to combine four bases into groups of three, called codons, the translation process uses only 20 amino acids. To account for the difference, multiple codons translate to the same amino acid. Leucine, for example, can be encoded in six ways.Scientists, however, have long speculated whether those seemingly synonymous codons truly produced the same amino acids, or whether they represented a second, hidden genetic code. Harvard researchers have deciphered that second code, and the answer may hold hope for developing new techniques to combat resistant bacteria.As described in a paper published online in the Proceedings of the National Academy of Sciences on Dec. 31, Arvind R. Subramaniam, a postdoctoral fellow in molecular and cellular biology, and Philippe Cluzel, professor of molecular and cellular biology and Gordon McKay Professor of Applied Physics, show that those seemingly synonymous parts of the genetic code are anything but. Under some stressful conditions, the researchers found, certain sequences manufacture proteins efficiently, while others — which are ostensibly identical — produce almost none.“It’s really quite remarkable, because it’s a very simple mechanism,” Subramaniam said. “Many researchers have tried to determine whether using different codons affects protein levels, but no one had thought that maybe you need to look at it under the right conditions to see this.”The first step, Subramaniam said, involved creating multiple copies of a gene that manufactures a fluorescent protein. To understand how the synonymous parts of the genetic code affect protein production, each version of the gene was designed to use a single way to code for a specific amino acid. In the case of serine, which can be encoded six ways, researchers created six versions of the gene. Those genes were then inserted into E. coli bacteria. Next, the E. coli bacteria experienced a stressful change in their environment. They were starved of amino acids, and the results were startling.“What we found was that if the bacteria are in an environment where they can grow and thrive, each synonymous codon produces the same amount of protein,” Subramaniam said. “But the moment we put them in an environment where they are starved of an amino acid, some codons produce a hundredfold more proteins than others.”The difference, he said, lay with molecules called transfer RNA, or tRNA, which ferry amino acids to the cellular machinery that manufactures proteins.“What we found was that some of these tRNA molecules are much more efficient at being loaded with amino acids, while others are less so,” Subramaniam said. “If these tRNA molecules can’t deliver the amino acid to where it needs to be, the cell cannot manufacture the proteins it needs. In an environment where amino acids are in short supply, that ability to hold onto them becomes very important.”While the system helps cells to make certain proteins efficiently under stressful conditions, it also acts as a biological failsafe, allowing the near-complete shutdown in the production of other proteins as a way to preserve limited resources.Given the universal nature of the genetic code — the system works the same way for all organisms, from single-celled bacteria to human beings — Subramaniam hopes to explore what role, if any, differences in the seemingly synonymous portions of the genetic code may have in other organisms, and whether those differences can be exploited by researchers.“One area that I’m interested in exploring is cancer,” he said. “We know that cancer cells grow very fast. As a result, they consume most of the amino acids in their environment. The question is whether this code plays any role in the disease. And if cancer cells do use the differences between these codons to express some protein it needs to survive, can we exploit that to combat the disease?”last_img read more

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The Fans Have Spoken! Your Top 10 Aaron Tveit Roles Revealed

first_imgLink Larkin, Hairspray William “Tripp” van der Bilt III, Gossip Girl Roger Davis, Rent Gabe, Next to Normal Aaron Tveit(Photos: USA,Universal Pictures and Michael Becker/FOX) You watched Grease: Live, you squealed at “Greased Lightning,” you told your friends at your Grease viewing party (you did have a Grease viewing party, didn’t you?!) that you totally knew Aaron Tveit way back when. Because you did. You really did. But then just as you were rolling on the high of “You’re the One That I Want,” we asked you to rank your favorite Aaron Tveit roles on Culturalist.com. And it was hard. And the night was not young. And you hunkered down and did it. Are we sorry? No, we are not. Below are your top 10 roles for our Broadway boyfriend. Read it and then get some rest. You deserve it. Enjolras, Les Miserables Fiyero, Wicked Star Files Mike Warren, Graceland Danny Zuko, Grease: Live John Wilkes Booth, Assassins View Comments Frank Abagnale Jr., Catch Me If You Can Aaron Tveitlast_img read more

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Latin America’s Drug Problem: Officials Meet to Share Strategies That Work

first_imgBy Dialogo September 09, 2013 Governments throughout the Western Hemisphere have begun taking a collaborative new approach to drugs, experimenting with different strategies and questioning the status quo. But one thing hasn’t changed in the age-old debate on how to curb illegal drug use: Easy solutions are elusive, and new ideas often raise more questions than answers. Earlier this month, officials from Brazil, Colombia, Guatemala and the United States grappled with these thorny questions at a panel discussion in Washington titled “The New Approach in the Americas toward the Global Problem of Drugs.” The Sept. 5 talk was part of the XVII Annual CAF Conference sponsored by the Development Bank of Latin America, the Organization of American States (OAS) and Inter-American Dialogue. It centered largely on the push to legalize the possession of small amounts of marijuana in nations such as Guatemala and Uruguay, and what that could mean for drug policy and security throughout the Americas. Nelson Jobim, Brazil’s former defense minister, warned that proponents of marijuana legalization haven’t been clear about the implications of such a seismic policy shift. For example, he said, legalization would in theory create different tiers of offenders — categories that law enforcement and the justice system would then need to sort out. “There would be criminal treatment for the traffickers and health treatment for consumers,” Jobim told the packed audience. “But if we legalize marijuana, what do we do with people who use [the drug] but are not addicted to it? What administrative consequences should there be?” Jobim: Drug legalization complicated on many levels Jobim said officials would need to untangle a host of other legal questions as well. Who, for example, decides on the amount of drugs an individual may consume for personal use — a judge, a doctor, the authorities? And if an addict commits a crime, should his drug use be taken into consideration as an aggravating factor? Regionally, legalization also creates certain dilemmas, he warned. “If we say drugs are transnational, we are correct,” Jobim said. But what if one nation legalizes two particular drugs, while a neighboring country legalizes four? And what about the possibility of drug-driven tourism? Would legalized drugs be considered a commodity? “How will we handle drugs moving between countries? How do we tax this?” asked Jobim, who said the key to resolving such questions is to have an honest, open dialogue. That’s precisely what’s happening, said Luís Fernando Carrera Castro, foreign minister of Guatemala. “For the first time in the Americas, we’ve established a platform for debate that’s separate from the old ideologies. We need to look at this problem into the future and not be stuck in the past,” said Carrera, adding that outdated laws must be rewritten. OAS urges open debate on hemispheric drug scourge Aside from the legalization debate, he explained, governments throughout the Americas are examining drug-fueled violence through a health and humanitarian prism. But he warned that illicit economies adapt quickly to new policies and that no panacea to the drug scourge exists. “We need to be careful about developing hope,” he said, cautioning that even innovative new policies won’t be “a silver bullet.” But Carrera did praise the OAS for wading into the complex issue and producing “a report that unifies and converges the debates of the past.” That comprehensive $2 million study, published in May, reflected on alternative approaches to the hemisphere’s drug problem, including legalization — which it said nations should explore in an effort to rein in spiraling violence and some of the world’s highest homicide rates. “The intensity of the violence associated with drug trafficking — especially in countries affected by the production, transit, and trafficking of illegal drugs — has been the principal factor in driving the concern of senior level officials in becoming more actively engaged in this debate,” OAS Secretary-General José Miguel Insulza wrote in the report’s introduction. Insulza: Debate on this topic ‘was overdue’ The 400-page review said regional trends “lean toward decriminalization or legalization of the production, sale and use of marijuana. Sooner or later, decisions in this area will need to be taken.” It added, however, that “other voices suggest it is premature to assume that current approaches to the subject have failed.” Speaking at the CAF panel, Insulza said collaboration is critical to tackling the drug problem, as are holistic strategies. “This is the only continent where every stage of drug production takes place,” Insulza said — from planting to shipping. Latin America suffers both the health consequences of drugs as well as the violent crime that comes with it. “The drug problem cannot be handled exclusively by law-enforcement methods,” he said, noting that tactics such as decriminalization, drug courts, rehabilitation, prevention and the social and economic aspects of drug abuse need to be addressed. Even so, Insulza said he was surprised by the study’s impact. “Half the headlines written about the OAS over the last year have been about the drug report, and most have been positive. That means a debate on this topic was overdue.” Kerlikowske: ‘We are all very much in this together’ Gil Kerlikowske, director of the White House Office of National Drug Control Policy, said his country strongly supports the OAS study. “There is no stronger advocate for drug reform policies than the United States,” Kerlikowske said, adding that the U.S. government devotes hundreds of millions of dollars to drug research, prevention and treatment programs. “We know that prevention is far less costly to taxpayers,” he said. “Some of the best methods of drug treatments have been developed in the United States.” Yet legalization is definitely not the answer, he argued. “We don’t think that legalizing drugs is going to improve public health, nor is it going to reduce violence and crime,” he said. “People recognize that the cartels have numerous funding streams … involving such things as kidnapping and extortion that are often far greater funding streams than what can be gained from drug trafficking.” But he stressed that the United States does understand that it is “our shared responsibility to reduce demand.” Progress has been made on that front. “Our appetite for cocaine, just since 2007, is down dramatically — by more than 40 percent,” Kerlikowske said. “We are all very much in this together. There is no such thing as a production country, as a transit country, or a consuming country,” he concluded. “So looking at how we can view and deal with this problem holistically without the finger-pointing I think is an important step in the right direction.” No, because some people want to work and there are no jobs. What happens is that, for example, I would be dealing with drugs already if it was up to me, because here you can’t find a job.last_img read more

adminDecember 20, 2020xdabuoLeave a Comment

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‘Confessional’ hears financial sins

first_img 11SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr Catholic Federal Credit Union in Saginaw, Mich., has created a “financial confessional” to start conversations with members about past financial wrongdoings and get them on the path to attaining financial goals.The confessional comes complete with a screen between two compartments to give it the feel of a real confessional.Windows in the front encourage users to take photos to share on social media platforms. The confessional’s sides feature examples of common financial mistakes, such as “I make minimum payments,” “We go out to eat too much,” and “I can’t afford to retire.”“Confessionals are an important part of the Catholic tradition,” says Bethany Dutcher, vice president of marketing at the $331 million asset credit union. continue reading »last_img read more

adminDecember 18, 2020xdabuoLeave a Comment

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To cut taxes, we need to cut spending

first_imgIf the county gives more money to the towns or reduces the amount that goes to the city, where will the money come from to pay for the various services of the county and the city?Won’t one tax bill go down and the other up?Part of the solution may be the redistribution of tax revenue. But the real solution is a decrease in spending by all branches of government.We don’t have a revenue problem — we have a spending problem.Jim VincentNiskayunaMore from The Daily Gazette:EDITORIAL: Thruway tax unfair to working motoristsEDITORIAL: Urgent: Today is the last day to complete the censusFoss: Should main downtown branch of the Schenectady County Public Library reopen?Puccioni’s two goals help Niskayuna boys’ soccer top Shaker, remain perfectEDITORIAL: Beware of voter intimidation Categories: Letters to the Editor, OpinionIt’s interesting to read about the distribution and “fair share” of Schenectady County sales taxes. Maybe I’m missing something.last_img read more

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What impact is COVID-19 having on Middle East conflicts?

first_imgSyriaThe COVID-19 outbreak turned into a pandemic just as a ceasefire reached by the two main foreign power brokers in Syria’s nine-year-old war — Russia and Turkey — was taking effect.The three million people living in the ceasefire zone, in the country’s northwestern region of Idlib, had little hope the deal would hold.Yet fears the coronavirus could spread like wildfire across the devastated country appear to have given the truce an extended lease of life. The novel coronavirus has put global trade on hold, placed half of the world population in confinement and has the potential to topple governments and reshape diplomatic relations.The United Nations has appealed for ceasefires in all the major conflicts rocking the planet, with its chief Antonio Guterres on Friday warning “the worst is yet to come”. But it remains unclear what the pandemic’s impact will be on the multiple wars roiling the Middle East.Here is an overview of the impact so far on the conflicts in Syria, Yemen, Libya and Iraq: According to the Syrian Observatory for Human Rights, the month of March saw the lowest civilian death toll since the conflict started in 2011, with 103 deaths.The ability of the multiple administrations in Syria — the Damascus government, the autonomous Kurdish administration in the northeast and the jihadist-led alliance that runs Idlib — to manage the coronavirus threat is key to their credibility.”This epidemic is a way for Damascus to show that the Syrian state is efficient and all territories should be returned under its governance,” analyst Fabrice Balanche said.However the pandemic and the global mobilisation it requires could precipitate the departure of US-led troops from Syria and neighbouring Iraq.This in turn could create a vacuum in which the Islamic State jihadist group, still reeling from the demise of its “caliphate” a year ago, could seek to step up its attacks.YemenThe Yemeni government and the Huthi rebels initially responded positively to the UN appeal for a ceasefire, as did neighbouring Saudi Arabia, which leads a military coalition in support of the government.That rare glimmer of hope in the five-year-old conflict was short-lived however and last week Saudi air defences intercepted ballistic missiles over Riyadh and a border city fired by the Iran-backed rebels.The Saudi-led coalition retaliated by striking Huthi targets in the rebel-held capital Sanaa on Monday.Talks have repeatedly faltered but the UN envoy Martin Griffiths is holding daily consultations in a bid to clinch a nationwide ceasefire.More flare-ups in Yemen could compound a humanitarian crisis often described as the worst in the world and invite a coronavirus outbreak of catastrophic proportions.In a country where the health infrastructure has collapsed, where water is a rare commodity and where 24 million people require humanitarian assistance, the population fears being wiped out if a ceasefire doesn’t allow for adequate aid.”People will end up dying on the streets, bodies will be rotting in the open,” said Mohammed Omar, a taxi driver in the Red Sea port city of Hodeida.LibyaMuch like Yemen, the main protagonists in the Libyan conflict initially welcomed the UN ceasefire call but swiftly resumed hostilities.Fierce fighting has rocked the south of the capital Tripoli in recent days, suggesting the risk of a major coronavirus outbreak is not enough to make guns fall silent.Turkey has recently played a key role in the conflict, throwing its weight behind the UN-recognised Government of National Accord.Fabrice Balanche predicted that accelerated Western disengagement from Middle East conflicts could limit Turkish support to the GNA.That could eventually favour forces loyal to eastern-based strongman Khalifa Haftar, who launched an assault on Tripoli one year ago and has the backing of Russia, Egypt and the United Arab Emirates.Western countries have been hit hardest by the pandemic, which could prompt them to divert both military resources and peace-brokering capacity from foreign conflicts.A report by the International Crisis Group said European officials had reported that efforts to secure a ceasefire in Libya were no longer receiving high-level attention due to the pandemic.IraqIraq is no longer gripped by fully-fledged conflict but it remains vulnerable to an IS resurgence in some regions and its two main foreign backers are at each other’s throats.Iran and the United States are two of the countries most affected by the coronavirus but there has been no sign of any let-up in their battle for influence that has largely played out on Iraqi soil.With most non-US troops in the coalition now gone and some bases evacuated, American personnel are now regrouped in a handful of locations in Iraq.Washington has deployed Patriot air defence missiles, prompting fears of a fresh escalation with Tehran, whose proxies it blames for a spate of rocket attacks on bases housing US troops.Topics :last_img read more

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MiFID II to spur greater ETF usage in securities lending – Moody’s

first_imgThe rollout of MiFID II could encourage institutional investors to make greater use of exchange-trade funds (ETFs) for securities lending and collateral purposes, according to a rating agency.This was because the new rules, effective yesterday, will lead to more information being available about trading volumes and liquidity.Before the MiFID II regime, ETF trades did not have to be reported, and, being largely transacted over-the-counter (OTC), this meant trading volumes and hence liquidity were understated.The new EU rules require ETF trades to be reported. Moody’s expects ETFs to become more widely used by institutional investors as part of securities lending as a result, according to Marina Cremonese, senior analyst at the credit rating agency.She said there has been a general trend towards increased use of non-cash assets as collateral in securities lending in the past decade. ETFs had been part of this, but in Europe their use had been constrained by a perception of low liquidity.#*#*Show Fullscreen*#*# Source: BLK Global Business Intelligence. NNB = Net New Business“As things become more transparent and we see the real volumes and liquidity associated with some ETFs we think institutional investors like banks, hedge funds, and asset managers, may use ETFs more as collateral,” she told IPE.Increased transparency brought about by MiFID II may also make it easier for pension funds to accept ETFs as collateral for securities lending, although liquidity will be only one of their considerations, she added.The MiFID II rules have come into effect after a buoyant year for ETFs.BlackRock yesterday said that its iShares business expanded at its fastest pace last year, with institutional investors deepening their usage of ETFs as financial instruments alongside bonds and derivatives in fast-growing buy-side to buy-side networked trading.It predicts the global ETF market will more than double in assets under management by 2022, said Mark Wiedman, global head of iShares and index investments at BlackRock.Colleague Stephen Cohen, head of iShares EMEA at BlackRock, said: “As the impact of MiFID II rules resound across the region we believe the European ETF industry is set for a new phase of growth.”The global ETF industry has more than $4.5trn (€3.7trn) of assets under management, according to BlackRock.See IPE’s November magazine for a guide on ETFs and this month’s magazine for a special report on investment research and MiFID IIlast_img read more

adminSeptember 29, 2020xdabuoLeave a Comment

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Atlas Delivers Unmanned Minesweeping System to Royal Navy

first_imgAtlas Elektronik UK has delivered an autonomous minesweeper system to Royal Navy, capable to clear sea lanes of mines.The system has been built by Atlas Elektronik, under a £13 million contract with the Ministry of Defence which has sustained around 20 jobs and created 15 new jobs with the company.The system’s technology has the ability to defeat the digital sea mines which can detect and target military ships passing overhead. The sweeper system, which features a ‘sense and avoid’ capability, could also work together with other similar autonomous systems for the common goal of making waters safer.The project also aims to demonstrate the viability of an unmanned system that can safely and successfully clear mines and which is designed to be operated from a land or ship-based control station and can be deployed from a suitable ship or port.Over the last four months, the system has been put through its paces by Atlas Elektronik and Defence Equipment and Support team members and the Royal Navy’s Maritime Autonomous Systems Trials Team (MASTT).The system was tested against a number of performance requirements, for example, how well it cleared mines, whether the autonomous system could successfully avoid obstacles and the overall system performance.Brigadier Jim Morris Royal Marines – assistant chief of the Naval Staff in Maritime Capability, and senior responsible officer for the Mine Counter Measures and Hydrographic Capability (MHC) programme said: “This autonomous sweep system represents a fundamental step in the Navy’s transition to autonomous offboard systems to counter the threat posed to international shipping by the sea mine, we look forward to commencing demonstration of the associated minehunting system in 2019.”The system will now undergo a series of more detailed trials with the Royal Navy.last_img read more

adminSeptember 28, 2020xdabuoLeave a Comment

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St. Louis Boys Hoopsters Get Wins

first_imgThe SLS 5th Grade Cardinals basketball team defeated Mt. Carmel Monday, November 10 by the score of 32-19.The Cardinals had a balanced scoring attack led by CJ Grote and Cody Mohr. Thomas Raver led the team in assists while Luke Wilson played aggressive defense and led the Cardinals in steals.The 5th grade is now 4-0 on the season.Courtesy of STL Coach Amrhein.The St. Louis Cardinals 6th grade boys basketball team were victorious tonight over Mt. Carmel 19-12.The Cardinals are now 4-0.Their next game is Thursday at Laurel.The Cardinals were led in scoring tonight by Leyton Ratcliffe and Sam Voegle with 4 pts. Kurt Siefert had 3 pts. Jack Abplanap, Max Giesting, Riley Schebler and Michael Wanstrath each had 2. The defense was led by Jack Forbeck and Jacob Sheets.Courtesy of STL Coach Rob Schebler.last_img read more

adminSeptember 24, 2020xdabuoLeave a Comment

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